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Literature summary extracted from

  • Satoh, Y.; Tajima, K.; Munekata, M.; Keasling, J.D.; Lee, T.S.
    Engineering of a tyrosol-producing pathway, utilizing simple sugar and the central metabolic tyrosine, in Escherichia coli (2012), J. Agric. Food Chem., 60, 979-984.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.39 4-hydroxyphenylacetaldehyde + NAD+ + H2O Escherichia coli
-
 4-hydroxyphenylacetate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.39 Escherichia coli
-
 BW25113
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.39 4-hydroxyphenylacetaldehyde + NAD+ + H2O
-
 Escherichia coli 4-hydroxyphenylacetate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.39 feaB
-
 Escherichia coli
1.2.1.39 PadA
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.39 NAD+
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
1.2.1.39 malfunction disruption of the endogenous phenylacetaldehyde dehydrogenase gene shuts off 4-hydroxyphenylacetate production and improves the production of tyrosol as a sole product Escherichia coli
1.2.1.39 metabolism FeaB plays a major role in the formation of 4-hydroxyphenylacetate Escherichia coli