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Literature summary extracted from

  • Jiang, L.L.; Zuo, Y.; Wang, Z.F.; Tan, Y.; Wu, Q.Y.; Xi, Z.; Yang, G.F.
    Design and syntheses of novel N-(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors (2011), J. Agric. Food Chem., 59, 6172-6179.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.4 agriculture the enzyme is a herbicidal target Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)thio)acetate
-
 Homo sapiens
1.3.3.4 methyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 methyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 additional information design and syntheses of N-(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors, herbicidal activities of the compounds, overview Homo sapiens
1.3.3.4 phenyl 2-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 2-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate
-
 Homo sapiens
1.3.3.4 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 3-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 3-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate
-
 Homo sapiens
1.3.3.4 phenyl 4-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate
-
 Homo sapiens
1.3.3.4 phenyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 phenyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 propan-2-yl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 propan-2-yl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 propyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 propyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens
1.3.3.4 S-(5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate
-
 Homo sapiens
1.3.3.4 S-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
 Homo sapiens
1.3.3.4 S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-methyl carbonothioate
-
 Homo sapiens
1.3.3.4 S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-phenyl carbonothioate
-
 Homo sapiens
1.3.3.4 tert-butyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2 Homo sapiens
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Homo sapiens protoporphyrin IX + 3 H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.3.4 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.3.4 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.3.4 FAD
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.3.4 0.00008
-
 S-(5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00011
-
 phenyl 3-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00018
-
 tert-butyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00021
-
 propan-2-yl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00025
-
 phenyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00028
-
 propyl [[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00029
-
 phenyl 2-[[5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00032
-
 phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00047
-
 S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-phenyl carbonothioate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00051
-
 S-[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl] O-phenyl carbonothioate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00052
-
 S-[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl] O-methyl carbonothioate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00075
-
 phenyl 4-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]butanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.0008
-
 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00122
-
 methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl)thio)acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00124
-
 propyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.0015
-
 propan-2-yl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00166
-
 phenyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00166
-
 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-2-methylpropanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00225
-
 methyl [[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00376
-
 phenyl 3-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00392
-
 methyl [[6-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]acetate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.00552
-
 phenyl 3-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.0859
-
 phenyl 2-[[6-chloro-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens
1.3.3.4 0.132
-
 phenyl 2-[[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-6-fluoro-1,3-benzothiazol-2-yl]sulfanyl]propanoate pH 7.5, 22°C, recombinant enzyme Homo sapiens