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Literature summary extracted from

  • Gogliettino, M.; Riccio, A.; Cocca, E.; Rossi, M.; Palmieri, G.; Balestrieri, M.
    A new pepstatin-insensitive thermopsin-like protease overproduced in peptide-rich cultures of Sulfolobus solfataricus (2014), Int. J. Mol. Sci., 15, 3204-3219.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.B25 additional information serine, metallo and aspartic protease inhibitors do not affect the enzyme activity, designating SsMTP-1 as a new member of the pepstatin-insensitive aspartic protease family Saccharolobus solfataricus
3.4.23.42 additional information not inhibitory: phenylmethylsulfonyl fluoride, EDTA, or pepstatin Saccharolobus solfataricus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.B25 extracellular
-
 Saccharolobus solfataricus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.B25 65103
-
 x * 65103, calculated from sequence Saccharolobus solfataricus
3.4.23.B25 75000
-
 x * 75000, SDS-PAGE Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.B25 additional information Saccharolobus solfataricus possible contribution in signal-transduction pathways ?
-
 ?
3.4.23.B25 additional information Saccharolobus solfataricus P2 possible contribution in signal-transduction pathways ?
-
 ?
3.4.23.B25 additional information Saccharolobus solfataricus DSM 1617 possible contribution in signal-transduction pathways ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.B25 Saccharolobus solfataricus Q97YX7
-
-
3.4.23.B25 Saccharolobus solfataricus P2 Q97YX7
-
-
3.4.23.42 Saccharolobus solfataricus Q97YX7
-
-
3.4.23.42 Saccharolobus solfataricus DSM 1617 Q97YX7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.B25
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.B25 Hemoglobin + H2O
-
 Saccharolobus solfataricus ?
-
 ?
3.4.23.B25 Hemoglobin + H2O
-
 Saccharolobus solfataricus P2 ?
-
 ?
3.4.23.B25 Hemoglobin + H2O
-
 Saccharolobus solfataricus DSM 1617 ?
-
 ?
3.4.23.B25 additional information possible contribution in signal-transduction pathways Saccharolobus solfataricus ?
-
 ?
3.4.23.B25 additional information possible contribution in signal-transduction pathways Saccharolobus solfataricus P2 ?
-
 ?
3.4.23.B25 additional information possible contribution in signal-transduction pathways Saccharolobus solfataricus DSM 1617 ?
-
 ?
3.4.23.B25 N-benzyloxycarbonyl-glycine 4-nitrophenyl ester
-
 Saccharolobus solfataricus ?
-
 ?
3.4.23.B25 oxidized insulin B chain + H2O
-
 Saccharolobus solfataricus ?
-
 ?
3.4.23.42 Hemoglobin + H2O
-
 Saccharolobus solfataricus ?
-
 ?
3.4.23.42 Hemoglobin + H2O
-
 Saccharolobus solfataricus P2 ?
-
 ?
3.4.23.42 Hemoglobin + H2O
-
 Saccharolobus solfataricus DSM 1617 ?
-
 ?
3.4.23.42 insulin B chain + H2O
-
 Saccharolobus solfataricus ? cleavage sites are Val-Asn, Cys-Gly, Leu-Tyr, Glu-Arg, Gly-Phe and Pro-Lys ?
3.4.23.42 insulin B chain + H2O
-
 Saccharolobus solfataricus P2 ? cleavage sites are Val-Asn, Cys-Gly, Leu-Tyr, Glu-Arg, Gly-Phe and Pro-Lys ?
3.4.23.42 insulin B chain + H2O
-
 Saccharolobus solfataricus DSM 1617 ? cleavage sites are Val-Asn, Cys-Gly, Leu-Tyr, Glu-Arg, Gly-Phe and Pro-Lys ?
3.4.23.42 N-CBZ-glycine 4-nitrophenyl ester + H2O
-
 Saccharolobus solfataricus N-CBZ-Gly + 4-nitrophenol
-
 ?
3.4.23.42 N-CBZ-glycine 4-nitrophenyl ester + H2O
-
 Saccharolobus solfataricus P2 N-CBZ-Gly + 4-nitrophenol
-
 ?
3.4.23.42 N-CBZ-glycine 4-nitrophenyl ester + H2O
-
 Saccharolobus solfataricus DSM 1617 N-CBZ-Gly + 4-nitrophenol
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.B25 ? x * 75000, SDS-PAGE Saccharolobus solfataricus
3.4.23.B25 ? x * 65103, calculated from sequence Saccharolobus solfataricus

Synonyms

EC Number Synonyms Comment Organism
3.4.23.B25 SsMTP-1
-
 Saccharolobus solfataricus
3.4.23.B25 SSO1175 locus name Saccharolobus solfataricus
3.4.23.42 MTP-1
-
 Saccharolobus solfataricus
3.4.23.42 SSO1175
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.B25 70
-
-
 Saccharolobus solfataricus
3.4.23.42 70
-
-
 Saccharolobus solfataricus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.23.B25 50 90 stable Saccharolobus solfataricus
3.4.23.42 50 90 stable within Saccharolobus solfataricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.B25 2
-
-
 Saccharolobus solfataricus
3.4.23.42 2
-
-
 Saccharolobus solfataricus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.23.B25 Saccharolobus solfataricus calculated from sequence
-
 6.2

General Information

EC Number General Information Comment Organism
3.4.23.B25 physiological function possible contribution in signal-transduction pathways Saccharolobus solfataricus