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Literature summary extracted from

  • Antoine, M.; Marcheteau, E.; Delagrange, P.; Ferry, G.; Boutin, J.
    Characterization of cofactors, substrates and inhibitor binding to flavoenzyme quinone reductase 2 by automated supramolecular nano-electrospray ionization mass spectrometry (2012), Int. J. Mass Spectrom., 312, 87-96.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.5.1 expression of recombinant QR2 in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 Melatonin
-
 Homo sapiens
1.10.5.1 additional information inhibitor binding structures, overview Homo sapiens
1.10.5.1 resveratrol
-
 Homo sapiens
1.10.5.1 S26695
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.5.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone Homo sapiens
-
 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.5.1 additional information QR2 is overexpressed in neurodegenerative diseases Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
 Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
 ?
1.10.5.1 additional information quinone reductase 2 (QR2) is implicated in the reduction of quinone in the presence of natural derivatives of NADH such as N-ribosyldihydronicotinamide. QR2 does not recognize NADH or NADPH as co-substrates, unlike quinone reductase 1 (QR1) Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.10.5.1 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 quinone reductase 2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.10.5.1 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.10.5.1 8.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD flavoenzyme, binding structure, overview. 2 molecules per enzyme dimer, quantification, overview Homo sapiens

General Information

EC Number General Information Comment Organism
1.10.5.1 malfunction specific inhibitors of QR2, tested in vivo, show outstanding properties impairing memory loss Homo sapiens
1.10.5.1 additional information QR2 does not share many features with QR1. Particularly, it does not seem to have a similar detoxifying function in cells. QR2 is overexpressed in neurodegenerative diseases Homo sapiens