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Literature summary extracted from

  • Teerawanichpan, P.; Robertson, A.J.; Qiu, X.
    A fatty acyl-CoA reductase highly expressed in the head of honey bee (Apis mellifera) involves biosynthesis of a wide range of aliphatic fatty alcohols (2010), Insect Biochem. Mol. Biol., 40, 641-649.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.50 heterologous expression of pYES2.1 plasmid harbouring AmFAR1 in Saccharomyces cerevisiae strain INVSc1 Apis mellifera

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.50 59200
-
 calculated from sequence Apis mellifera

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.50 Apis mellifera D9MWM7 honey bee
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.50 head predominance, expression level of AmFAR1 in head approximately three times higher than in thorax and abdomen Apis mellifera
-
1.2.1.50 additional information AmFAR1 ubiquitously expressed in all body segments Apis mellifera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.50 a long-chain fatty acyl-CoA + NADPH + H+ AmFAR1 converts saturated fatty acids ranging from 16 to 22 carbon chains to their corresponding alcohols with the highest conversion efficiency shown on 18:0, AmFAR1 also shows some activities on ricinoleic acid, 16:1n-7 and 18:1n-9 Apis mellifera a long-chain aldehyde + CoA + NADP+ aldehyde intermediate is immediately reduced to the corresponding alcohol ?
1.2.1.50 additional information no activity observed on 18:2n-6 and 18:3n-3 Apis mellifera ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.50 AmFAR1
-
 Apis mellifera
1.2.1.50 fatty acyl-CoA reductase
-
 Apis mellifera

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.50 35
-
-
 Apis mellifera

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.2.1.50 15 40
-
 Apis mellifera

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.50 7 7.5
-
 Apis mellifera

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.50 NADPH no activity with NADH Apis mellifera

General Information

EC Number General Information Comment Organism
1.2.1.50 metabolism enzyme is involved in the conversion of a wide range of fatty acids to their corresponding alcohols, which are the essential components of pheromones, wax esters or ether lipids Apis mellifera