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Literature summary extracted from

  • Hong, S.K.; Chaturvedi, R.; Piazuelo, M.B.; Coburn, L.A.; Williams, C.S.; Delgado, A.G.; Casero, R.A.; Schwartz, D.A.; Wilson, K.T.
    Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity (2010), Inflamm. Bowel Dis., 16, 1557-1566.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.3.16 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.16 spermine + O2 + H2O Homo sapiens
-
 spermidine + 3-aminopropanal + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.16 epithelial cell
-
 Homo sapiens
-
1.5.3.16 macrophage
-
 Homo sapiens
-
1.5.3.16 mononuclear cell mononuclear inflammatory cells Homo sapiens
-
1.5.3.16 additional information immunohistochemic detection of enzyme expression in different tissue during inflammation, overview Homo sapiens
-
1.5.3.16 stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 spermine + O2 + H2O
-
 Homo sapiens spermidine + 3-aminopropanal + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.16 SMO
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.5.3.16 Homo sapiens increased expression of spermine oxidase in ulcerative colitis and in prostate cancer and prostate intraepithelial neoplasia tissues. SMO expression is upregulated in gastritis tissues from patients with Helicobacter pylori infection, it is upregulated in both macrophages and epithelial cells up

General Information

EC Number General Information Comment Organism
1.5.3.16 physiological function involvement of SMO in gastritic mucosal inflammation, SMO expression is increased in human prostate cancer and prostate intraepithelial neoplasia tissues. Polyamines are ubiquitous, polycationic alkylamines that are essential for eukaryotic cell growth and differentiation, and play an important role in inflammation-induced carcinogenesis. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity Homo sapiens