Literature summary extracted from

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I.
The indoleamine 2,3-dioxygenase inhibitor 1-methyl-tryptophan suppresses mitochondrial function, induces aerobic glycolysis and decreases interleukin-10 production in human lymphocytes (2012), Immunol. Invest., 41, 507-520.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.52	1-methyl-DL-tryptophan	-	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.13.11.52	45000	-	x * 45000	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.52	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.52	lymphocyte	-	Homo sapiens	-

Subunits

EC Number	Subunits	Comment	Organism
1.13.11.52	?	x * 45000	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
1.13.11.52	IDO	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
1.13.11.52	malfunction	hemodialysis patients characterized by impaired adaptive immunity, exhibit increased IDO expression, further enhanced in the non-responders to hepatitis B virus vaccination	Homo sapiens
1.13.11.52	metabolism	indoleamine 2,3-dioxygenase catalyses the initial rate-limiting step of tryptophan degradation along the kynurenine pathway	Homo sapiens
1.13.11.52	physiological function	indoleamine 2,3-dioxygenase suppresses adaptive immunity. It induces T-cell differentiation to regulatory T-cells through tryptophan depletion and/or kynurenine pathway products. The enzyme decreases glucose uptake by stimulated lymphocytes, increases mitochondrial function in stimulated lymphocytes, decreases aerobic glycolysis in stimulated lymphocytes, and induces the production of the immunosuppressive cytokine IL-10 by stimulated lymphocytes. Effect of IDO on glucose metabolism of lymphocytes, overview	Homo sapiens

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Release 2023.1 (January 2023)