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Literature summary extracted from

  • Tesone, A.J.; Regueira, E.; Canosa, L.F.; Ceballos, N.R.
    5alpha-Reductase, an enzyme regulating glucocorticoid action in the testis of Rhinella arenarum (Amphibia: Anura) (2012), Gen. Comp. Endocrinol., 176, 500-506.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 additional information enzyme is not inhibited by finasteride Rhinella arenarum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.000569
-
 corticosterone pH 7.4, 28°C Rhinella arenarum
1.3.1.22 0.00119
-
 testosterone pH 7.4, 28°C Rhinella arenarum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Rhinella arenarum
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rhinella arenarum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 testis
-
 Rhinella arenarum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 corticosterone + NADPH + H+
-
 Rhinella arenarum 5alpha-dihydrocorticosterone + NADP+
-
 ?
1.3.1.22 additional information neither Km nor Vmax for both corticosterone and testosterone are significantly different among reproductive periods Rhinella arenarum ?
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Rhinella arenarum 5alpha-dihydrotestosterone + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 7 8
-
 Rhinella arenarum