EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.5.3.16 | HIV-1 Tat | Tat-induced SMO activation, involving the polyamine-sensitive subtype of the NMDA receptor, the activation is completely prevented by the NMDAR antagonist MK-801. Mechanism, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.3.16 | spermine + O2 + H2O | Homo sapiens | - |
spermidine + 3-aminopropanal + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.3.16 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.3.16 | brain | - |
Homo sapiens | - |
1.5.3.16 | neuroblastoma cell | - |
Homo sapiens | - |
1.5.3.16 | SH-SY5Y cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.3.16 | spermine + O2 + H2O | - |
Homo sapiens | spermidine + 3-aminopropanal + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.3.16 | SMO | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.5.3.16 | Homo sapiens | ability of Tat to upregulate the activity of spermine oxidase, the polyamine catabolic enzyme that specifically oxidizes spermine, with the production of spermidine, H2O2, and 3-aminopropanal, through stimulation of the NMDA receptor, mechanism, overview | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.5.3.16 | physiological function | spermine oxidase plays a role as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. HIV-1 Tat protein is found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase. Pretreatment of cells with N-acetylcysteine, a scavenger of H2O2, and with MK-801 is able to completely inhibit reactive oxygen species formation and to restore cell viability, overview | Homo sapiens |