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Literature summary extracted from

  • Umair, S.; Bland, R.J.; Simpson, H.V.
    Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta (2012), Exp. Parasitol., 131, 101-106.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.8 0.4
-
 L-lysine enzyme from L3 larva, at pH 7.0, temperature not specified in the publication Haemonchus contortus
1.5.1.8 0.5
-
 L-lysine enzyme from L3 larva, at pH 7.0, temperature not specified in the publication Teladorsagia circumcincta
1.5.1.8 0.7
-
 L-lysine enzyme from adult, at pH 7.0, temperature not specified in the publication Haemonchus contortus
1.5.1.8 0.9
-
 L-lysine enzyme from adult, at pH 7.0, temperature not specified in the publication Teladorsagia circumcincta
1.5.1.21 1.4
-
 DELTA1-piperideine-2-carboxylate at pH 6.5 temperature not specified in the publication Haemonchus contortus
1.5.1.21 1.6
-
 DELTA1-piperideine-2-carboxylate at pH 6.5, temperature not specified in the publication Teladorsagia circumcincta

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.5.1.8 Ca2+ 0.5 mM Ca+ used in assay conditions Haemonchus contortus
1.5.1.8 Ca2+ 0.5 mM Ca+ used in assay conditions Teladorsagia circumcincta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADH + H+ Haemonchus contortus
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADH + H+ Teladorsagia circumcincta
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH + H+ Haemonchus contortus
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH + H+ Teladorsagia circumcincta
-
 N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADH Haemonchus contortus
-
 L-pipecolate + NAD+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADH Teladorsagia circumcincta
-
 L-pipecolate + NAD+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADPH Haemonchus contortus
-
 L-pipecolate + NADP+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADPH Teladorsagia circumcincta
-
 L-pipecolate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.15 no activity in Haemonchus contortus
-
-
-
1.4.1.15 no activity in Teladorsagia circumcincta
-
-
-
1.5.1.8 Haemonchus contortus
-
-
-
1.5.1.8 Teladorsagia circumcincta
-
-
-
1.5.1.21 Haemonchus contortus
-
-
-
1.5.1.21 Teladorsagia circumcincta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.8 adult
-
 Haemonchus contortus
-
1.5.1.8 adult
-
 Teladorsagia circumcincta
-
1.5.1.8 larva
-
 Haemonchus contortus
-
1.5.1.8 larva
-
 Teladorsagia circumcincta
-
1.5.1.21 adult
-
 Haemonchus contortus
-
1.5.1.21 adult
-
 Teladorsagia circumcincta
-
1.5.1.21 additional information enzyme activity is not detected in the L3 larva Haemonchus contortus
-
1.5.1.21 additional information enzyme activity is not detected in the L3 larva Teladorsagia circumcincta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADH + H+
-
 Haemonchus contortus N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADH + H+
-
 Teladorsagia circumcincta N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH + H+
-
 Haemonchus contortus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH + H+
-
 Teladorsagia circumcincta N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADH
-
 Haemonchus contortus L-pipecolate + NAD+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADH
-
 Teladorsagia circumcincta L-pipecolate + NAD+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADPH
-
 Haemonchus contortus L-pipecolate + NADP+
-
 ?
1.5.1.21 DELTA1-piperideine-2-carboxylate + NADPH
-
 Teladorsagia circumcincta L-pipecolate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.8 LKR
-
 Haemonchus contortus
1.5.1.8 LKR
-
 Teladorsagia circumcincta
1.5.1.8 lysine ketoglutarate reductase
-
 Haemonchus contortus
1.5.1.8 lysine ketoglutarate reductase
-
 Teladorsagia circumcincta
1.5.1.21 DELTA1-piperideine-2-carboxylate reductase
-
 Haemonchus contortus
1.5.1.21 DELTA1-piperideine-2-carboxylate reductase
-
 Teladorsagia circumcincta
1.5.1.21 Pip2CR
-
 Haemonchus contortus
1.5.1.21 Pip2CR
-
 Teladorsagia circumcincta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.8 7
-
-
 Haemonchus contortus
1.5.1.8 7
-
-
 Teladorsagia circumcincta
1.5.1.21 6.5
-
-
 Haemonchus contortus
1.5.1.21 6.5
-
-
 Teladorsagia circumcincta

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.8 NAD+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Haemonchus contortus
1.5.1.8 NAD+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Teladorsagia circumcincta
1.5.1.8 NADP+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Haemonchus contortus
1.5.1.8 NADP+ dual co-factor enzyme, not specific for either NAD+ or NADP+ Teladorsagia circumcincta
1.5.1.21 NADH
-
 Haemonchus contortus
1.5.1.21 NADH
-
 Teladorsagia circumcincta
1.5.1.21 NADPH
-
 Haemonchus contortus
1.5.1.21 NADPH
-
 Teladorsagia circumcincta