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Literature summary extracted from

  • Parker, R.O.; Crouch, R.K.
    Retinol dehydrogenases (RDHs) in the visual cycle (2010), Exp. Eye Res., 91, 788-792.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.315 11-cis-retinol-[retinal-binding-protein] + NAD+ Mus musculus
-
 11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.315 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.315 eye
-
 Mus musculus
-
1.1.1.315 retinal pigment epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.315 11-cis-retinol-[retinal-binding-protein] + NAD+
-
 Mus musculus 11-cis-retinal-[retinol-binding-protein] + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.315 RDH5
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.315 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.315 malfunction 11-cis retinol oxidation occurs at a reduced rate in retinal pigment epithelium membranes from Rdh5-/- mice Mus musculus
1.1.1.315 metabolism RDH11, which can can utilize both cis and trans-retinoid substrates, plays a minor but complementary role to RDH5 in the flow of retinoids during dark adaptation Mus musculus
1.1.1.315 physiological function isomerization of 11-cis retinal to all-trans retinal in photoreceptors is the first step in vision. In the retinal pigment epithelium, all-trans retinol is converted to 11-cis retinol, and in the final enzymatic step, 11-cis-retinol is oxidized to 11-cis retinal, catalyzed by the enzyme RDH5. RDH5 does play a significant role in 11-cis retinol oxidation in the retinal pigment epithelium Mus musculus