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Literature summary extracted from

  • Sykes, S.E.; Hajduk, S.L.
    Dual functions of alpha-ketoglutarate dehydrogenase E2 in the Krebs cycle and mitochondrial DNA inheritance in Trypanosoma brucei (2013), Eukaryot. Cell, 12, 78-90.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.105 inner membrane
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 Trypanosoma brucei
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-
1.2.1.105 mitochondrial matrix
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 Trypanosoma brucei 5759
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Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Trypanosoma brucei
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 alpha-KDE2
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 Trypanosoma brucei
1.2.1.105 dihydrolipoyl succinyltransferase E2 part of the multisubunit alpha-ketoglutarate dehydrogenase complex Trypanosoma brucei

General Information

EC Number General Information Comment Organism
1.2.1.105 malfunction RNAi knockdown-inducted bloodstream trypanosomes show pronounced growth reduction and often fail to equally distribute kinetoplast DNA to daughter cells, resulting in accumulation of cells devoid of kinetoplast DNA or containing two kinetoplasts Trypanosoma brucei
1.2.1.105 physiological function the enzyme is bifunctional, both as a metabolic enzyme and as a mitochondrial inheritance factor necessary for the distribution of kinetoplast DNA networks to daughter cells at cytokinesis Trypanosoma brucei