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Literature summary extracted from
- Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase (2013), Drug Metab. Dispos., 41, 24-29.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.3.1 | beta-estradiol | - |
Homo sapiens |  |
| 1.2.3.1 | chlorpromazine | - |
Homo sapiens | |
| 1.2.3.1 | clozapine | - |
Homo sapiens | |
| 1.2.3.1 | domperidone | - |
Homo sapiens | |
| 1.2.3.1 | ethinyl estradiol | - |
Homo sapiens | |
| 1.2.3.1 | hydralazine | 100 microM reduces enzyme activity by as much as 96% | Homo sapiens | |
| 1.2.3.1 | menadione | - |
Homo sapiens | |
| 1.2.3.1 | additional information | addition of 100 microM allopurinol has no significant effect on enzyme activity | Homo sapiens | |
| 1.2.3.1 | raloxifene | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.3.1 | 0.0063 | - |
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide | pH 7.4 and 37°C | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2 | N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent | Homo sapiens | DACA-9(10H)-acridone + H2O2 | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.3.1 | 0.0000023 | - |
raloxifene | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.00043 | - |
ethinyl estradiol | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.00047 | - |
menadione | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.00062 | - |
chlorpromazine | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.00087 | - |
beta-estradiol | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.0012 | - |
domperidone | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.0015 | - |
menadione | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.0036 | - |
ethinyl estradiol | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.0044 | - |
beta-estradiol | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
| 1.2.3.1 | 0.0051 | - |
clozapine | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
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