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Literature summary extracted from

  • Luis, P.B.; Ruiter, J.P.; Ijlst, L.; Tavares de Almeida, I.; Duran, M.; Mohsen, A.W.; Vockley, J.; Wanders, R.J.; Silva, M.F.
    Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase in the metabolism of valproic acid: implications for the branched-chain amino acid oxidation pathway (2011), Drug Metab. Dispos., 39, 1155-1160.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.4 valproyl-CoA competitive Rattus norvegicus
1.3.8.4 valproyl-dephosphoCoA competitive Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.4 0.125
-
 isovaleryl-CoA pH 8.0, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.4 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.8.4 isovaleryl-CoA + FAD Rattus norvegicus
-
 3-methylcrotonyl-CoA + FADH2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.4 Rattus norvegicus P12007
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.4 isovaleryl-CoA + FAD
-
 Rattus norvegicus 3-methylcrotonyl-CoA + FADH2
-
 ?
1.3.8.4 isovaleryl-CoA + FAD with ferrocenium hexafluorophosphate as second electron acceptor Rattus norvegicus 3-methylcrotonyl-CoA + FADH2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.4 IVD
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.8.4 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.8.4 8
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.4 FAD
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.8.4 additional information
-
 additional information inhibition kinetics, overview Rattus norvegicus
1.3.8.4 0.074
-
 valproyl-CoA versus isovaleryl-CoA, pH 8.0, 37°C Rattus norvegicus
1.3.8.4 0.17
-
 valproyl-dephosphoCoA versus isovaleryl-CoA, pH 8.0, 37°C Rattus norvegicus