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Literature summary extracted from

  • Stiborova”, M.; Dracinska”, H.; Marti­nek, V.; Svaskova”, D.; Hodek, P.; Milichovsky, J.; Hejdukova”, Z.; Brotanek, J.; Schmeiser, H.; Frei, E.
    Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I) (2013), Chem. Res. Toxicol., 26, 290-299.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.2 cytosol
-
 Rattus norvegicus 5829
-
1.6.5.2 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 NADH + H+ + 2-methyl-1,4-naphthoquinone Rattus norvegicus
-
 NAD+ + 2-methyl-1,4-naphthoquinol
-
 ?
1.6.5.2 NADPH + H+ + 2-methyl-1,4-naphthoquinone Rattus norvegicus
-
 NADP+ + 2-methyl-1,4-naphthoquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 kidney
-
 Rattus norvegicus
-
1.6.5.2 liver
-
 Rattus norvegicus
-
1.6.5.2 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 NADH + H+ + 2-methyl-1,4-naphthoquinone
-
 Rattus norvegicus NAD+ + 2-methyl-1,4-naphthoquinol
-
 ?
1.6.5.2 NADPH + H+ + 2-methyl-1,4-naphthoquinone
-
 Rattus norvegicus NADP+ + 2-methyl-1,4-naphthoquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase 1
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NADH
-
 Rattus norvegicus
1.6.5.2 NADPH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.6.5.2 Rattus norvegicus Sudan I induces NQO1 expression in rat liver, kidney, and lung, real-time polymerase chain reaction expression analysis up