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Literature summary extracted from

  • Blanco, G.; Patallo, E.P.; Brana, A.F.; Trefzer, A.; Bechthold, A.; Rohr, J.; Mendez, C.; Salas, J.A.
    Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin (2001), Chem. Biol., 8, 253-263.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.331 expression in Streptomyces lividans Streptomyces olivaceus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C Streptomyces olivaceus the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
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 ?
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C Streptomyces olivaceus Tü2353 the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.331 Streptomyces olivaceus Q9F2F9
-
-
2.4.1.331 Streptomyces olivaceus Tü2353 Q9F2F9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin Streptomyces olivaceus dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
-
 ?
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C dTDP-beta-L-rhamnose i.e. dTDP-6-deoxy-beta-L-mannose Streptomyces olivaceus dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
-
 ?
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin Streptomyces olivaceus Tü2353 dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
-
 ?
2.4.1.331 dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C dTDP-beta-L-rhamnose i.e. dTDP-6-deoxy-beta-L-mannose Streptomyces olivaceus Tü2353 dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
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 ?
2.4.1.331 additional information when the elloramycin gene cluster is transformed into the mithramycin producer, Streptomyces argillaceus, four compounds are produced by the recombinant strain: the elloramycin aglycon 8-demethyl-tetracenomycin C and three glycosylated derivatives. Two of them contained a D-olivose or a D-mycarose moiety attached to the aglycon, 8-demethyl-8-beta-D-olivosyl-tetracenomycin C and 8-demethyl-8-beta-D-mycarosyl-tetracenomycin C. The third one contains a diolivosyl disaccharide attached to the aglycon, 8-demethyl-8-beta-D-diolivosyl-3'-1''-D-L-tetracenomycin C. The enzyme transfesr individually D-olivose and D-mycarose or a diolivosyl disaccharide to the aglycon 8-demethyl-tetracenomycin C Streptomyces olivaceus ?
-
 ?
2.4.1.331 additional information when the elloramycin gene cluster is transformed into the mithramycin producer, Streptomyces argillaceus, four compounds are produced by the recombinant strain: the elloramycin aglycon 8-demethyl-tetracenomycin C and three glycosylated derivatives. Two of them contained a D-olivose or a D-mycarose moiety attached to the aglycon, 8-demethyl-8-beta-D-olivosyl-tetracenomycin C and 8-demethyl-8-beta-D-mycarosyl-tetracenomycin C. The third one contains a diolivosyl disaccharide attached to the aglycon, 8-demethyl-8-beta-D-diolivosyl-3'-1''-D-L-tetracenomycin C. The enzyme transfesr individually D-olivose and D-mycarose or a diolivosyl disaccharide to the aglycon 8-demethyl-tetracenomycin C Streptomyces olivaceus Tü2353 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.331 ElmGT
-
 Streptomyces olivaceus

General Information

EC Number General Information Comment Organism
2.4.1.331 metabolism the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin Streptomyces olivaceus