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Literature summary extracted from

  • Moreb, J.S.; Ucar, D.; Han, S.; Amory, J.K.; Goldstein, A.S.; Ostmark, B.; Chang, L.J.
    The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance (2012), Chem. Biol. Interact., 195, 52-60.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.2.1.3 medicine ALDH isoenzymes play a major role in the biology and drug resistance of various malignant cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 expressed in Escherichia coli K-562 and H-1299 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 diethylaminobenzaldehyde 0.025 mM diethylaminobenzaldehyde inhibits about 80% of the enzymatic activity Homo sapiens
1.2.1.3 Disulfiram 0.025 mM diethylaminobenzaldehyde inhibits about 20-30% of the enzymatic activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens P05091
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 propionaldehyde + NAD+ + H2O
-
 Homo sapiens propionate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.2.1.3 physiological function the proliferation rate and the ability to form colonies is significantly increased by the overexpression of isoform ALDH2 Homo sapiens