Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rizner, T.; Lin, H.; Penning, T.
    Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells (2003), Chem. Biol. Interact., 143-144, 401-409.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.357 expressed in COS-1 cells, PC-3 cells, and LNCaP cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.357 5alpha-dihydrotestosterone + NAD(P)H + H+ Homo sapiens
-
 3alpha-androstanediol + NAD(P)+
-
 ?
1.1.1.357 additional information Homo sapiens isoform AKR1C2 functions preferentially as a 3-ketosteroid reductase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.357 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.357 prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.357 3alpha-androstanediol + NAD+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADH + H+
-
 ?
1.1.1.357 5alpha-dihydrotestosterone + NAD(P)H + H+
-
 Homo sapiens 3alpha-androstanediol + NAD(P)+
-
 ?
1.1.1.357 5alpha-dihydrotestosterone + NADPH + H+
-
 Homo sapiens 3alpha-androstanediol + NADP+
-
 ?
1.1.1.357 additional information isoform AKR1C2 functions preferentially as a 3-ketosteroid reductase Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.357 AKR1C2 isoform Homo sapiens
1.1.1.357 bile acid binding protein
-
 Homo sapiens
1.1.1.357 type 3 3alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.357 NAD+ preferred cofactor for oxidation Homo sapiens
1.1.1.357 NADPH preferred cofactor for reduction Homo sapiens