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Literature summary extracted from

  • Rosado, L.A.; Caceres, R.A.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
    Role of Serine140 in the mode of action of Mycobacterium tuberculosis beta-ketoacyl-ACP Reductase (MabA) (2012), BMC Res. Notes, 5, 526.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.100 expressed in Escherichia coli Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.100 S140A mutant shows no enzymatic activity. S140A mutant does not bind to NADPH Mycobacterium tuberculosis
1.1.1.100 S140T mutant shows no enzymatic activity. Mutant S140T shows impaired NADPH binding Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.100 acetoacetyl-CoA + NADPH + H+
-
 Mycobacterium tuberculosis D-3-hydroxybutyryl-CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.100 beta-ketoacyl-ACP reductase
-
 Mycobacterium tuberculosis
1.1.1.100 MabA
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.100 25
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.100 7
-
 assay at Mycobacterium tuberculosis