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Literature summary extracted from

  • Bazil, J.N.; Vinnakota, K.C.; Wu, F.; Beard, D.A.
    Analysis of the kinetics and bistability of ubiquinol:cytochrome c oxidoreductase (2013), Biophys. J., 105, 343-355.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.8 additional information
-
 additional information steady-state equation for the six-state system model, substrate binding affinities under different conditions, overview Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.8 mitochondrial inner membrane
-
 Mammalia 5743
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.8 Fe2+ Rieske iron-sulfur protein Mammalia
7.1.1.8 Mg2+ lowers the substrate binding affinities Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.8 quinol + 2 ferricytochrome c Mammalia
-
 quinone + 2 ferrocytochrome c + 2 H+
-
 ?
7.1.1.8 ubiquinol + 2 ferricytochrome c Mammalia
-
 ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.8 Mammalia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.8 quinol + 2 ferricytochrome c
-
 Mammalia quinone + 2 ferrocytochrome c + 2 H+
-
 ?
7.1.1.8 ubiquinol + 2 ferricytochrome c
-
 Mammalia ubiquinone + 2 ferrocytochrome c + 2 H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.8 bc1 complex
-
 Mammalia
7.1.1.8 ubiquinol:cytochrome c oxidoreductase
-
 Mammalia

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.1.1.8 25
-
 assay at Mammalia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1.1.8 7
-
 assay at Mammalia

General Information

EC Number General Information Comment Organism
7.1.1.8 additional information model of the bc1 complex for mammalian mitochondria incorporating the major redox centers near the Qo- and Qi-site of the enzyme, and including the pH-dependent redox reactions, overview. The model consists of six distinct states characterized by the mobile electron distribution in the enzyme Mammalia
7.1.1.8 physiological function the bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane. The complex is also implicated in the generation of reactive oxygen species under certain conditions and is thus a contributor to cellular oxidative stress Mammalia