Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Luniwal, A.; Wang, L.; Pavlovsky, A.; Erhardt, P.W.; Viola, R.E.
    Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase (2012), Bioorg. Med. Chem., 20, 2950-2956.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.11
-
 Streptococcus pneumoniae
1.2.1.11
-
 Vibrio cholerae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 (1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 (1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 (2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
-
 Streptococcus pneumoniae
1.2.1.11 (2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
-
 Vibrio cholerae
1.2.1.11 (3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
-
 Streptococcus pneumoniae
1.2.1.11 (3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
-
 Vibrio cholerae
1.2.1.11 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
-
 Streptococcus pneumoniae
1.2.1.11 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
-
 Vibrio cholerae
1.2.1.11 (3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
-
 Streptococcus pneumoniae
1.2.1.11 (3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
-
 Vibrio cholerae
1.2.1.11 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Streptococcus pneumoniae
1.2.1.11 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Vibrio cholerae
1.2.1.11 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Streptococcus pneumoniae
1.2.1.11 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
 Vibrio cholerae
1.2.1.11 (7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
-
 Vibrio cholerae
1.2.1.11 (7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 (7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 2-Aminoadipate
-
 Streptococcus pneumoniae
1.2.1.11 2-Aminoadipate
-
 Vibrio cholerae
1.2.1.11 4-nitro-N,N-diethylbenzimidazolinone
-
 Streptococcus pneumoniae
1.2.1.11 4-nitro-N,N-diethylbenzimidazolinone
-
 Vibrio cholerae
1.2.1.11 4-nitro-N,N-dimethylbenzimidazolinone
-
 Streptococcus pneumoniae
1.2.1.11 4-nitro-N,N-dimethylbenzimidazolinone
-
 Vibrio cholerae
1.2.1.11 4-nitro-N-ethylphthalimide
-
 Streptococcus pneumoniae
1.2.1.11 4-nitro-N-ethylphthalimide
-
 Vibrio cholerae
1.2.1.11 4-nitro-N-methylphthalimide
-
 Streptococcus pneumoniae
1.2.1.11 4-nitro-N-methylphthalimide
-
 Vibrio cholerae
1.2.1.11 5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
-
 Vibrio cholerae
1.2.1.11 dimethyl pyridine-2,5-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 dimethyl pyridine-2,5-dicarboxylate
-
 Vibrio cholerae
1.2.1.11 methyl 5-nitropyridine-2-carboxylate
-
 Streptococcus pneumoniae
1.2.1.11 methyl 5-nitropyridine-2-carboxylate
-
 Vibrio cholerae
1.2.1.11 thieno[2,3-b]thiophene-2,5-dicarboxylate
-
 Streptococcus pneumoniae
1.2.1.11 thieno[2,3-b]thiophene-2,5-dicarboxylate
-
 Vibrio cholerae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Streptococcus pneumoniae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Vibrio cholerae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Streptococcus pneumoniae
-
-
-
1.2.1.11 Vibrio cholerae Q9KQG2
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.11
-
 Streptococcus pneumoniae
1.2.1.11
-
 Vibrio cholerae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Streptococcus pneumoniae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Vibrio cholerae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 ASADH
-
 Streptococcus pneumoniae
1.2.1.11 ASADH
-
 Vibrio cholerae
1.2.1.11 aspartate semialdehyde dehydrogenase
-
 Streptococcus pneumoniae
1.2.1.11 aspartate semialdehyde dehydrogenase
-
 Vibrio cholerae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADPH
-
 Streptococcus pneumoniae
1.2.1.11 NADPH
-
 Vibrio cholerae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.11 0.086
-
 4-nitro-N,N-dimethylbenzimidazolinone in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 0.086
-
 4-nitro-N,N-dimethylbenzimidazolinone in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 0.11
-
 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 0.15
-
 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 0.18
-
 (3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 0.18
-
 (1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 0.4
-
 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 0.69
-
 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 0.89
-
 4-nitro-N-methylphthalimide in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 1.1
-
 4-nitro-N-methylphthalimide in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 1.1
-
 (3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 1.2
-
 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 1.2
-
 (2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 2.1
-
 (2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 2.6
-
 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 3.3
-
 (3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 4
-
 4-nitro-N-ethylphthalimide Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 4
-
 4-nitro-N-ethylphthalimide Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 4
-
 4-nitro-N,N-diethylbenzimidazolinone Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 4
-
 4-nitro-N,N-diethylbenzimidazolinone Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 20
-
 methyl 5-nitropyridine-2-carboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 20
-
 methyl 5-nitropyridine-2-carboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 20
-
 dimethyl pyridine-2,5-dicarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 20
-
 dimethyl pyridine-2,5-dicarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae
1.2.1.11 20
-
 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Streptococcus pneumoniae
1.2.1.11 20
-
 5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C Vibrio cholerae