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Literature summary extracted from

  • Rodrigues, R.F.; Castro-Pinto, D.; Echevarria, A.; dos Reis, C.M.; Del Cistia, C.N.; SantAnna, C.M.; Teixeira, F.; Castro, H.; Canto-Cavalheiro, M.; Leon, L.L.; Tomas, A.
    Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies (2012), Bioorg. Med. Chem., 20, 1760-1766.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride non-competitive inhibition, 76% inhibition at 0.001 mM Leishmania amazonensis
1.8.1.12 2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride non-competitive inhibition, 69.5% inhibition at 0.001 mM Leishmania braziliensis
1.8.1.12 2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride non-competitive inhibition, 70% inhibition at 0.001 mM Leishmania infantum
1.8.1.12 2-[(E)-2-(4-nitrophenyl)ethenyl]-3-phenyl-5-(phenylamino)-2,5-dihydro-1,3,4-thiadiazol-3-ium chloride non-competitive inhibition, 83% inhibition at 0.001 mM Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH + H+ Trypanosoma cruzi
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania amazonensis
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania infantum
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania braziliensis
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Trypanosoma cruzi Y
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania amazonensis MHOM/BR/LTB0016
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania infantum MHOM/MA67ITMAP263
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+ Leishmania braziliensis MCAN/BR/98/R619
-
 trypanothione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Leishmania amazonensis
-
-
-
1.8.1.12 Leishmania amazonensis MHOM/BR/LTB0016
-
-
-
1.8.1.12 Leishmania braziliensis
-
-
-
1.8.1.12 Leishmania braziliensis MCAN/BR/98/R619
-
-
-
1.8.1.12 Leishmania infantum
-
-
-
1.8.1.12 Leishmania infantum MHOM/MA67ITMAP263
-
-
-
1.8.1.12 Trypanosoma cruzi
-
-
-
1.8.1.12 Trypanosoma cruzi Y
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.12 epimastigote
-
 Trypanosoma cruzi
-
1.8.1.12 epimastigote
-
 Leishmania amazonensis
-
1.8.1.12 epimastigote
-
 Leishmania infantum
-
1.8.1.12 epimastigote
-
 Leishmania braziliensis
-
1.8.1.12 promastigote
-
 Trypanosoma cruzi
-
1.8.1.12 promastigote
-
 Leishmania amazonensis
-
1.8.1.12 promastigote
-
 Leishmania infantum
-
1.8.1.12 promastigote
-
 Leishmania braziliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania amazonensis trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania infantum trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania braziliensis trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Trypanosoma cruzi Y trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania amazonensis MHOM/BR/LTB0016 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania infantum MHOM/MA67ITMAP263 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH + H+
-
 Leishmania braziliensis MCAN/BR/98/R619 trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 trypanothione reductase
-
 Trypanosoma cruzi
1.8.1.12 trypanothione reductase
-
 Leishmania amazonensis
1.8.1.12 trypanothione reductase
-
 Leishmania infantum
1.8.1.12 trypanothione reductase
-
 Leishmania braziliensis
1.8.1.12 TryR
-
 Trypanosoma cruzi
1.8.1.12 TryR
-
 Leishmania amazonensis
1.8.1.12 TryR
-
 Leishmania infantum
1.8.1.12 TryR
-
 Leishmania braziliensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
 Trypanosoma cruzi
1.8.1.12 FAD
-
 Leishmania amazonensis
1.8.1.12 FAD
-
 Leishmania infantum
1.8.1.12 FAD
-
 Leishmania braziliensis
1.8.1.12 NADPH
-
 Trypanosoma cruzi
1.8.1.12 NADPH
-
 Leishmania amazonensis
1.8.1.12 NADPH
-
 Leishmania infantum
1.8.1.12 NADPH
-
 Leishmania braziliensis