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Literature summary extracted from

  • Takao, K.; Shirahata, A.; Samejima, K.; Casero, R.A.; Igarashi, K.; Sugita, Y.
    Pentamines as substrate for human spermine oxidase (2013), Biol. Pharm. Bull., 36, 407-411.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.3.16 gene hSMO, expression in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.16 N1,N4-bis(2,3-butadienyl)-1,4 butanediamine i.e. MDL72527 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.16 additional information
-
additional information Michaelis-Menten kinetics, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.3.16 cytosol
-
Homo sapiens 5829
-
1.5.3.16 nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.16 spermine + O2 + H2O Homo sapiens
-
spermidine + 3-aminopropanal + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Homo sapiens
-
gene hSMO
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 1,16-diamino-4,8,13-triazahexadecane pentahydrochloride + O2 + H2O
-
Homo sapiens ?
-
?
1.5.3.16 additional information substrate activities of human spermine oxidase with various linear polyamines, overview. N1-acetyl-spermine is a poor substrate. H2O2 is measured by a HPLC method that analyzed fluorescent dimers derived from the oxidation of homovanillic acid in the presence of horseradish peroxidase Homo sapiens ?
-
?
1.5.3.16 N1-ethyl-spermine + O2 + H2O good substrate Homo sapiens spermidine + N-ethyl-3-aminopropanal + H2O2
-
?
1.5.3.16 spermine + O2 + H2O
-
Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?
1.5.3.16 spermine + O2 + H2O preferred substrate Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.16 SMO
-
Homo sapiens
1.5.3.16 Spm oxidase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.3.16 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.3.16 9
-
assay at Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.5.3.16 7 9 the activity markedly decreases from pH 9.0 to pH 7.0 Homo sapiens