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Literature summary extracted from

  • Wang, Y.; Goodwin, D.C.
    Integral role of the I-helix in the function of the "inactive" C-terminal domain of catalase-peroxidase (KatG) (2013), Biochim. Biophys. Acta, 1834, 362-371.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 E695A only subtle variations in spectroscopic and catalytic properties of the enzyme, substantial decrease in the rate and extent of KatG N-terminal domain reactivation Mycobacterium tuberculosis
1.11.1.21 E695A/Y697A substantial increase in hexa-coordinate low-spin heme and diminished enzyme activity, complete loss of the capacity for the reactivation of the N-terminal domain Mycobacterium tuberculosis
1.11.1.21 L690A/R691A substantial increase in hexa-coordinate low-spin heme and diminished enzyme activity, complete loss of the capacity for the reactivation of the N-terminal domain Mycobacterium tuberculosis
1.11.1.21 L690A/R691A/E695A/Y697A substantial increase in hexa-coordinate low-spin heme and diminished enzyme activity, complete loss of the capacity for the reactivation of the N-terminal domain Mycobacterium tuberculosis
1.11.1.21 R691A only subtle variations in spectroscopic and catalytic properties of the enzyme, substantial decrease in the rate and extent of KatG N-terminal domain reactivation Mycobacterium tuberculosis
1.11.1.21 Y697A only subtle variations in spectroscopic and catalytic properties of the enzyme, substantial decrease in the rate and extent of KatG N-terminal domain reactivation Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.21 1.2
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 1.9
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2.2
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A/E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2.4
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2.7
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2.7
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2.9
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 3.3
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 3.6
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 4
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 4.5
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 6
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
Mycobacterium tuberculosis ? + H2O
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.1.21 160
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A/E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 1020
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 1050
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2200
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2700
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 3500
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 4000
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 4800
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 6800
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 8300
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 8900
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 11500
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, pH 7.0, 23°C Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.11.1.21 70
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A/E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 200
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 600
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 800
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 850
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A/Y697A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 900
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 1700
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant L690A/R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 1700
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, N- and C-terminal domain separately expressed, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2500
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant R691A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 2500
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) wild-type, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 3100
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant E695A, pH 7.0, 23°C Mycobacterium tuberculosis
1.11.1.21 4400
-
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) mutant Y697A, pH 7.0, 23°C Mycobacterium tuberculosis