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Literature summary extracted from
- Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases (2011), Biochim. Biophys. Acta, 1810, 1262-1271.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.B1 | medicine | the enzyme is a drug target in schistosomiasis | Schistosoma mansoni |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.1.B1 | U597C | the mutant displays significantly decreased enzyme activities compared to the wild type enzyme | Schistosoma mansoni |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.B1 | auranofin | very potent inhibitor, nearly compete inhibition at 0.01 mM | Schistosoma mansoni |  |
| 1.8.1.B1 | furoxan | i.e. oxadiazole-3-carbonitrile-2-oxide, potent inhibitor | Schistosoma mansoni | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.B1 | cytoplasm | - |
Schistosoma mansoni | 5737 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.B1 | 65000 | - |
2 * 65000 | Schistosoma mansoni |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.B1 | GSSG + NADPH + H+ | Schistosoma mansoni | - |
GSH + NADP+ | - |
? | |
| 1.8.1.B1 | thioredoxin disulfide + NADPH + H+ | Schistosoma mansoni | - |
thioredoxin + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.B1 | Schistosoma mansoni | Q962Y6 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.B1 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Schistosoma mansoni | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.B1 | GSSG + NADPH + H+ | - |
Schistosoma mansoni | GSH + NADP+ | - |
? | |
| 1.8.1.B1 | thioredoxin disulfide + NADPH + H+ | - |
Schistosoma mansoni | thioredoxin + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.1.B1 | homodimer | 2 * 65000 | Schistosoma mansoni |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.B1 | TGR | also know as TXNRD3/TrxR3 | Schistosoma mansoni |
| 1.8.1.B1 | thioredoxin-glutathione reductase | - |
Schistosoma mansoni |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.B1 | FAD | - |
Schistosoma mansoni | |
| 1.8.1.B1 | NADPH | - |
Schistosoma mansoni | |
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Release 2023.1 (January 2023)
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