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Literature summary extracted from

  • Unitt, D.; Hollis, V.; Palacios-Callender, M.; Frakich, N.; Moncada, S.
    Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions (2010), Biochim. Biophys. Acta, 1797, 371-377.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 nitric oxide nitric oxide that is not inactivated inhibits the cytochrome c oxidase, reducing the enzyme and lowering O2 consumption Homo sapiens
7.1.1.9 Sodium azide the addition of 0.5 mM sodium azide at 0.1 mM O2during the initial purging process results in a maximal reduction in cytochrome c oxidase redox state Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.9 ferricytochrome c + H2O Homo sapiens
-
 ferrocytochrome c + O2 + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 embryonic kidney
-
 Homo sapiens
-
7.1.1.9 Tet-iNOS-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferricytochrome c + H2O
-
 Homo sapiens ferrocytochrome c + O2 + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 cytochrome c oxidase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
7.1.1.9 metabolism the cytochrome c oxidase plays an important role in regulating endogenous nitric oxide concentrations Homo sapiens