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Literature summary extracted from

  • Kalashnikov, D.S.; Grivennikova, V.G.; Vinogradov, A.D.
    Submitochondrial fragments of brain mitochondria: general characteristics and catalytic properties of NADH:ubiquinone oxidoreductase (complex I) (2011), Biochemistry (Moscow), 76, 209-216.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.2 alamethicin slight stimulation Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 DTNB
-
 Sus scrofa
7.1.1.2 piericidin specific inhibitor of ubiquinone reduction Sus scrofa
7.1.1.2 rotenone specific inhibitor of ubiquinone reduction Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrial inner membrane activities of submitochondrial fragments from heart and brain, overview Sus scrofa 5743
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.2 Fe2+ iron-sulfur center Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.2 NADH + ubiquinone + 6 H+[side 1] Sus scrofa
-
 NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 brain
-
 Sus scrofa
-
7.1.1.2 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 additional information hexaammineruthenium (III) chloride, i.e. HAR, can act as artificial electron acceptor. The rate of NADH oxidation by the artificial electron acceptor HAR is about 10fold higher than NADH oxidase activity and is insensitive to rotenone and piericidin Sus scrofa ?
-
 ?
7.1.1.2 NADH + ubiquinone + 6 H+[side 1]
-
 Sus scrofa NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Sus scrofa
7.1.1.2 NADH:HAR (III) reductase
-
 Sus scrofa
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.1.1.2 25 30 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1.1.2 8
-
 assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH the NADH binding site is located in the matrix of mitochondria and their inner membrane is impermeable for NADH Sus scrofa