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Literature summary extracted from

  • Zay, A.; Choy, F.Y.; Patrick, C.; Sinclair, G.
    Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts (2011), Biochem. Cell Biol., 89, 299-307.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.4.2 expressed in Pichia pastoris strain GS115 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.4.2 glycine + H-protein-lipoyllysine Homo sapiens
-
 H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.4.2 Homo sapiens P23434
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.4.2 Ni-NTA column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.4.2 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.4.2 glycine + H-protein-lipoyllysine
-
 Homo sapiens H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.4.2 GDC
-
 Homo sapiens
1.4.4.2 glycine cleavage enzyme complex
-
 Homo sapiens
1.4.4.2 H-protein
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.4.4.2 physiological function the H-protein interacts with the L-protein, which is also part of the L-ketoglutarate dehydrogenase complex Homo sapiens