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Literature summary extracted from

  • Qian, Y.; West, C.M.; Kornfeld, S.
    UDP-GlcNAc:Glycoprotein N-acetylglucosamine-1-phosphotransferase mediates the initial step in the formation of the methylphosphomannosyl residues on the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins (2010), Biochem. Biophys. Res. Commun., 393, 678-681.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.17 Dictyostelium discoideum
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.17 UDP-N-acetyl-D-glucosamine + methyl alpha-D-mannopyranoside
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 Dictyostelium discoideum UMP + methyl (6-O-alpha-N-acetyl-D-glucosaminylphospho)-alpha-D-mannopyranoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.17 gpt1
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 Dictyostelium discoideum
2.7.8.17 UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase
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 Dictyostelium discoideum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.17 37
-
 assay at Dictyostelium discoideum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.17 7.4
-
 assay at Dictyostelium discoideum

General Information

EC Number General Information Comment Organism
2.7.8.17 malfunction extracts of two mutant cell lines transfer UDP-N-acetyl-D-glucosamine from N-acetyl-D-glucosamine to mannose residues at less than 5% the wild type value. In addition, the lysosomal hydrolases of these mutant clones fail to bind to a cation-independent mannose 6-phosphate receptor affinity column Dictyostelium discoideum