EC Number | Application | Comment | Organism |
---|---|---|---|
2.5.1.122 | synthesis | the specific 4-O-prenylation of tyrosine derivatives by SirD could find usage for production of prenylated tyrosine derivatives by chemoenzymatic synthesis | Leptosphaeria maculans |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.122 | overproduction of His6-SirD in Escherichia coli | Leptosphaeria maculans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.122 | dimethylallyl diphosphate + L-tyrosine | Leptosphaeria maculans | the enzyme is involved in biosynthesis of sirodesmin PL | diphosphate + 4-O-dimethylallyl-L-tyrosine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.122 | Leptosphaeria maculans | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.122 | - |
Leptosphaeria maculans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.122 | dimethylallyl diphosphate + 3-amino-L-tyrosine | SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Amino-L-tyrosine is prenylated with 108% of the activity compared to L-tyrosine | Leptosphaeria maculans | diphosphate + 3-amino-4-O-dimethylallyl-L-tyrosine | - |
? | |
2.5.1.122 | dimethylallyl diphosphate + 3-fluoro-DL-tyrosine | SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Iodo-L-tyrosine is prenylated with 53.6% of the activity compared to L-tyrosine | Leptosphaeria maculans | diphosphate + 4-O-dimethylallyl-3-fluoro-DL-tyrosine | - |
? | |
2.5.1.122 | dimethylallyl diphosphate + 3-iodo-L-tyrosine | SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives. 3-Iodo-L-tyrosine is prenylated with 27.3% of the activity compared to L-tyrosine | Leptosphaeria maculans | diphosphate + 4-O-dimethylallyl-3-iodo-L-tyrosine | - |
? | |
2.5.1.122 | dimethylallyl diphosphate + L-tyrosine | the enzyme is involved in biosynthesis of sirodesmin PL | Leptosphaeria maculans | diphosphate + 4-O-dimethylallyl-L-tyrosine | - |
? | |
2.5.1.122 | dimethylallyl diphosphate + L-tyrosine | SirD catalyzes the regiospecific O-prenylation at position C4 of tyrosine and derivatives | Leptosphaeria maculans | diphosphate + 4-O-dimethylallyl-L-tyrosine | - |
? | |
2.5.1.122 | additional information | SirD also catalyses the C-prenylation of L-Trp derivatives, in addition to the O-prenylation | Leptosphaeria maculans | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.122 | SirD | - |
Leptosphaeria maculans |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.122 | 37 | - |
assay at | Leptosphaeria maculans |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.122 | 7.5 | - |
assay at | Leptosphaeria maculans |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.122 | physiological function | the enzyme is involved in biosynthesis of sirodesmin PL | Leptosphaeria maculans |