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Literature summary extracted from

  • Naumann, J.M.; Zoellner, A.; Dragan, C.A.; Messinger, J.; Adam, J.; Bureik, M.
    Biotechnological production of 20-alpha-dihydrodydrogesterone at pilot scale (2011), Appl. Biochem. Biotechnol., 165, 190-203.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.149 biotechnology a process is developed that that allows the production of 20alpha- dihydrodydrogesterone at technical scale (several grams of 20a-DHD per week and fermenter). Genetic improvement of the production strain, an increase of substrate solubility by addition of ß-cyclodextrin, and the development of a sophisticated high-cell density fermentation at pilot scale are employed. By usage of the exemplary substrate progesterone, it is hsown that this innovative fission yeast-based whole cell biotransformation process is transferable to the conversion of other AKR1C1 substrates without special adaptation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.149 recombinantly expressed in fission yeast cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 progesterone + NADH
-
 Homo sapiens 20alpha-hydroxyprogesterone + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 20alpha-HSD
-
 Homo sapiens
1.1.1.149 20alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.149 AKR1C1
-
 Homo sapiens