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Literature summary extracted from

  • Zhu, L.; Lin, J.; Ma, J.; Cronan, J.; Wang, H.
    Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase (2010), Antimicrob. Agents Chemother., 54, 689-698.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9 expression in Escherichia coli Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.9 0.691
-
 crotonyl-[acyl-carrier protein] pH 7.0, temperature not specified in the publication Pseudomonas aeruginosa
1.3.1.9 0.704
-
 trans-2-decenoyl-[acyl-carrier protein] pH 7.0, temperature not specified in the publication Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Pseudomonas aeruginosa Q9HZP8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-[acyl-carrier protein] + NADH + H+
-
 Pseudomonas aeruginosa butyryl-[acyl-carrier protein] + NAD+
-
 ?
1.3.1.9 trans-2-decenoyl-[acyl-carrier protein] + NADH + H+
-
 Pseudomonas aeruginosa decanoyl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 FabV
-
 Pseudomonas aeruginosa
1.3.1.9 PA2950
-
 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
1.3.1.9 physiological function isoform FabV confers triclosan resistance on Pseudomonas aeruginosa. Upon deletion of the fabV gene, the mutant strain becomes more than 2000fold more sensitive to triclosan than the wild-type strain. Enzyme functionally replaces Escherichia coli fabI in vivo and renders Escherichia coli resistant to triclosan Pseudomonas aeruginosa