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Literature summary extracted from

  • Sacchi, S.; Caldinelli, L.; Cappelletti, P.; Pollegioni, L.; Molla, G.
    Structure-function relationships in human D-amino acid oxidase (2012), Amino Acids, 43, 1833-1850.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 3-hydroxyquinoline-2-(1H)-one very potent inhibitor Homo sapiens
1.4.3.3 4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
1.4.3.3 5-methylpyrazole-3-carboxylic acid
-
 Homo sapiens
1.4.3.3 6-chlorobenzo[d]isoxazol-3-ol
-
 Homo sapiens
1.4.3.3 anthranilate
-
 Homo sapiens
1.4.3.3 benzoate competitive inhibitor Homo sapiens
1.4.3.3 chlorpromazine
-
 Homo sapiens
1.4.3.3 D-serine
-
 Homo sapiens
1.4.3.3 trifluoro-D-alanine pseudo-substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.3 1.3
-
 D-alanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 1.5
-
 D-tryptophan at pH 7.0 and 25°C Homo sapiens
1.4.3.3 1.5
-
 D-Dopa at pH 7.0 and 25°C Homo sapiens
1.4.3.3 1.5
-
 D-tyrosine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 2.7
-
 D-phenylalanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 7.5
-
 D-serine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 8.5
-
 D-proline at pH 7.0 and 25°C Homo sapiens
1.4.3.3 180
-
 glycine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 2000
-
 D-Aspartate at pH 7.0 and 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.3 peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-amino acid + H2O + O2 Homo sapiens
-
 2-oxocarboxylate + NH3 + H2O2
-
 ?
1.4.3.3 D-kynurenine + H2O + O2 Homo sapiens
-
 kynurenic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Homo sapiens low catalytic efficiency and substrate affinity on the physiological substrate D-serine 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Homo sapiens
-
1.4.3.3 brain cortex
-
 Homo sapiens
-
1.4.3.3 cerebellum
-
 Homo sapiens
-
1.4.3.3 glial cell
-
 Homo sapiens
-
1.4.3.3 medulla oblongata
-
 Homo sapiens
-
1.4.3.3 additional information not detected in the forebrain Homo sapiens
-
1.4.3.3 pons
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-amino acid + H2O + O2
-
 Homo sapiens 2-oxocarboxylate + NH3 + H2O2
-
 ?
1.4.3.3 D-aspartate + H2O + O2
-
 Homo sapiens oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.3 D-DOPA + H2O + O2
-
 Homo sapiens 3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-kynurenine + H2O + O2
-
 Homo sapiens kynurenic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-phenylalanine + H2O + O2
-
 Homo sapiens phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2
-
 Homo sapiens 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 low catalytic efficiency and substrate affinity on the physiological substrate D-serine Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Homo sapiens indol-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tyrosine + H2O + O2
-
 Homo sapiens 4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 glycine + H2O + O2
-
 Homo sapiens glyoxylate + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.3 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 DAAO
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.3 0.9
-
 glycine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 3
-
 D-serine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 3.2
-
 D-tryptophan at pH 7.0 and 25°C Homo sapiens
1.4.3.3 5.2
-
 D-alanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 6.6
-
 D-phenylalanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 6.7
-
 D-Aspartate at pH 7.0 and 25°C Homo sapiens
1.4.3.3 10.2
-
 D-proline at pH 7.0 and 25°C Homo sapiens
1.4.3.3 14.8
-
 D-tyrosine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 21.7
-
 D-Dopa at pH 7.0 and 25°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.3 0.007
-
 benzoate at pH 7.0 and 25°C Homo sapiens
1.4.3.3 0.7
-
 chlorpromazine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 0.7
-
 trifluoro-D-alanine at pH 7.0 and 25°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.000004
-
 at pH 7.0 and 25°C Homo sapiens 3-hydroxyquinoline-2-(1H)-one
1.4.3.3 0.000141
-
 at pH 7.0 and 25°C Homo sapiens 4H-furo[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.000145
-
 at pH 7.0 and 25°C Homo sapiens 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
1.4.3.3 0.00018
-
 at pH 7.0 and 25°C Homo sapiens 6-chlorobenzo[d]isoxazol-3-ol
1.4.3.3 0.00091
-
 at pH 7.0 and 25°C Homo sapiens 5-methylpyrazole-3-carboxylic acid

General Information

EC Number General Information Comment Organism
1.4.3.3 malfunction a total loss of enzymatic activity is associated with the adult onset of familial amyotrophic lateral sclerosis. Altered enzyme expression levels and activity have been reported in schizophrenia Homo sapiens
1.4.3.3 physiological function the enzyme is part responsible for the significant increases in brain kynurenic acid levels seen under inflammatory conditions Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.4.3.3 0.003
-
 D-Aspartate at pH 7.0 and 25°C Homo sapiens
1.4.3.3 0.005
-
 glycine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 0.4
-
 D-serine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 1.3
-
 D-proline at pH 7.0 and 25°C Homo sapiens
1.4.3.3 2.1
-
 D-tryptophan at pH 7.0 and 25°C Homo sapiens
1.4.3.3 2.4
-
 D-phenylalanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 4
-
 D-alanine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 9.9
-
 D-tyrosine at pH 7.0 and 25°C Homo sapiens
1.4.3.3 14.5
-
 D-Dopa at pH 7.0 and 25°C Homo sapiens