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Literature summary extracted from

  • Ohtsubo, K.
    Biological significance of N-acetylglucosaminyltransferase-IV-mediated protein glycosylation on the homeostasis of cellular physiological functions (2011), Trends Glycosci. Glycotechnol., 23, 103-105.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.145 Bos taurus
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-
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2.4.1.145 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.145 choriocarcinoma cell
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 Homo sapiens
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2.4.1.145 choriocarcinoma cell
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 Bos taurus
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2.4.1.145 gastrointestinal tract isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes Bos taurus
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2.4.1.145 leukocyte isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes Bos taurus
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2.4.1.145 additional information isoform GnT-IVb is ubiquitously and constitutively expressed among tissues Homo sapiens
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2.4.1.145 peripheral blood
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 Bos taurus
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.145 GnT-IVa iozyme Bos taurus
2.4.1.145 GnT-IVb iozyme Homo sapiens
2.4.1.145 Mgat4a
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 Bos taurus
2.4.1.145 Mgat4b
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 Homo sapiens
2.4.1.145 N-acetylglucosaminyltransferase-IV
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 Homo sapiens
2.4.1.145 N-acetylglucosaminyltransferase-IV
-
 Bos taurus

Expression

EC Number Organism Comment Expression
2.4.1.145 Bos taurus Mgat4a expression levels are significantly reduced in the pancreatic beta cells of type 2 diabetes patients down
2.4.1.145 Bos taurus Mgat4a expression is induced under hypoxic conditions. Isoform GnT-IVa expression is aberrantly up-regulated in some type of tumor cells up

General Information

EC Number General Information Comment Organism
2.4.1.145 metabolism N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V Homo sapiens
2.4.1.145 metabolism N-acetylglucosaminyltransferase-IV synthesizes the GlcNAcbeta(1-4) branch structure on the Manalpha(1-3) arm of N-glycan core, and is essential for the production of multiantennary N-glycans cooperatively with N-acetylglucosaminyltransferase-V Bos taurus