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Literature summary extracted from

  • Graham, T.R.; Burd, C.G.
    Coordination of Golgi functions by phosphatidylinositol 4-kinases (2011), Trends Cell Biol., 21, 113-121.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.7.1.67 endoplasmic reticulum at Golgi-endoplasmic reticulum contact points Saccharomyces cerevisiae 5783
-
2.7.1.67 Golgi apparatus at Golgi-endoplasmic reticulum contact points Saccharomyces cerevisiae 5794
-
2.7.1.67 Golgi apparatus principal PI4Ks of the Golgi apparatus are PI4KIIalpha and PI4KIIIbeta Homo sapiens 5794
-
2.7.1.67 membrane
-
 Homo sapiens 16020
-
2.7.1.67 membrane
-
 Saccharomyces cerevisiae 16020
-
2.7.1.67 nucleus PI4KIIIbeta shuttles through the nucleus Homo sapiens 5634
-
2.7.1.67 nucleus Pik1 shuttles through the nucleus. Nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion Saccharomyces cerevisiae 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ required Homo sapiens
2.7.1.67 Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Saccharomyces cerevisiae
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Homo sapiens
-
-
-
2.7.1.67 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.67 phosphoprotein yeast Pik1 is phosphorylated by a protein kinase, phosphorylation promotes dissociation of Pik1 from Golgi membranes and association with the 14-3-3 proteins Bmh1 and Bmh2 in the cytosol Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol 4-kinase
-
 Homo sapiens
2.7.1.67 phosphatidylinositol 4-kinase
-
 Saccharomyces cerevisiae
2.7.1.67 PI4K
-
 Homo sapiens
2.7.1.67 PI4K
-
 Saccharomyces cerevisiae
2.7.1.67 Pik1
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.67 ATP
-
 Homo sapiens
2.7.1.67 ATP
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.7.1.67 metabolism regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview Homo sapiens
2.7.1.67 metabolism regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview Saccharomyces cerevisiae
2.7.1.67 additional information nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion Saccharomyces cerevisiae
2.7.1.67 physiological function phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis Homo sapiens
2.7.1.67 physiological function phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis Saccharomyces cerevisiae