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Literature summary extracted from

  • Takeuchi, H.; Fernandez-Valdivia, R.C.; Caswell, D.S.; Nita-Lazar, A.; Rana, N.A.; Garner, T.P.; Weldeghiorghis, T.K.; Macnaughtan, M.A.; Jafar-Nejad, H.; Haltiwanger, R.S.
    Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase (2011), Proc. Natl. Acad. Sci. USA, 108, 16600-16605.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.26 Homo sapiens
-
-
-
2.4.2.26 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine Rumi transfers D-xylose or D-glucose to serine 52 in the O-glucose consensus sequence (50CASSPC55) of factor VII EGF repeat. The second serine (S53) facilitates transfer of Xyl, but not glucose, to the EGF repeat by Rumi. EGF16 of mouse Notch2, which has a diserine motif in the consensus sequence (587CYSSPC592), is also modified with either O-Xyl or O-glucose glycans in cells Mus musculus UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine Rumi transfers D-xylose or D-glucose to serine 52 in the O-glucose consensus sequence (50CASSPC55) of factor VII EGF repeat. The second serine (S53) facilitates transfer of Xyl, but not glucose, to the EGF repeat by Rumi. EGF16 of mouse Notch2, which has a diserine motif in the consensus sequence (587CYSSPC592), is also modified with either O-Xyl or O-glucose glycans in cells Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.26 Rumi in addition to protein O-glucosyltransferase activity, both human and mouse Rumi also show protein O-xylosyltransferase activity Mus musculus
2.4.2.26 Rumi in addition to protein O-glucosyltransferase activity, both human and mouse Rumi also show protein O-xylosyltransferase activity Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.26 37
-
 assay at Mus musculus
2.4.2.26 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.26 7
-
 assay at Mus musculus
2.4.2.26 7
-
 assay at Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.2.26 Mus musculus XT-I gene expression is down-regulated by IL-1beta down
2.4.2.26 Homo sapiens XT-I gene expression is down-regulated by IL-1beta down
2.4.2.26 Mus musculus XT-I gene expression is up-regulated by TGF-beta1 up
2.4.2.26 Homo sapiens XT-I gene expression is up-regulated by TGF-beta1 up