Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Toy, G.; Austin, W.R.; Liao, H.I.; Cheng, D.; Singh, A.; Campbell, D.O.; Ishikawa, T.O.; Lehmann, L.W.; Satyamurthy, N.; Phelps, M.E.; Herschman, H.R.; Czernin, J.; Witte, O.N.; Radu, C.G.
    Requirement for deoxycytidine kinase in T and B lymphocyte development (2010), Proc. Natl. Acad. Sci. USA, 107, 5551-5556.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.74 additional information deletion of exon 3 inactivates dCK function. Generation of enzyme knockout mice that show 90fold decrease in thymic cellularity compared to wild-type, lymphocyte numbers in the dCK KO mice are 5 to 13fold below normal values Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 NTP + deoxycytidine Mus musculus
-
 NDP + dCMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 B-lymphocyte
-
 Mus musculus
-
2.7.1.74 bone marrow
-
 Mus musculus
-
2.7.1.74 T-lymphocyte
-
 Mus musculus
-
2.7.1.74 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
 Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Mus musculus NDP + dCMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.74 malfunction dCK inactivation selectively and profoundly affects T and B cell development, severe impact of dCK inactivation on lymphopoiesis. Inactivation of dCK induces a partial block in B cell development Mus musculus
2.7.1.74 metabolism dCK function in the context of cytosolic deoxycytidine metabolism, model, overview Mus musculus
2.7.1.74 physiological function deoxycytidine kinase is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. The enzyme phosphorylates and therefore activates nucleoside analogue prodrugs frequently used in cancer, autoimmunity, and viral infections. Normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway Mus musculus