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Literature summary extracted from

  • Leblanc, C.; Prudhomme, T.; Tabouret, G.; Ray, A.; Burbaud, S.; Cabantous, S.; Mourey, L.; Guilhot, C.; Chalut, C.
    4-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo (2012), PLoS Pathog., 8, e1003097.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.8.7 medicine isoform PptT is a target for anti-tuberculosis drugs Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.7 expressed in Escherichia coli BL21(DE3)DELTAentD cells Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.7 mitochondrion
-
Mycobacterium tuberculosis 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.7 Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Mycobacterium tuberculosis
-
adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Mycobacterium tuberculosis BCG
-
adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.7 Mycobacterium tuberculosis
-
-
-
2.7.8.7 Mycobacterium tuberculosis BCG
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.7 amylose affinity column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
Mycobacterium tuberculosis adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?
2.7.8.7 CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
Mycobacterium tuberculosis BCG adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.7 4-phosphopantetheinyl transferase
-
Mycobacterium tuberculosis
2.7.8.7 PPTase
-
Mycobacterium tuberculosis
2.7.8.7 PptT isoform Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.7 30
-
-
Mycobacterium tuberculosis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.8.7 7 8
-
Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.8.7 4'-phosphopantetheine
-
Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.8.7 metabolism isoform PptT plays a role in the biosynthesis pathways for mycolic acids, polyketide-derived lipids and siderophores Mycobacterium tuberculosis
2.7.8.7 physiological function the enzyme is required for Mycobacterium tuberculosis growth and persistence in vivo. The enzyme is involved in post-translational modification of various type-I polyketide synthases required for the formation of both mycolic acids and lipid virulence factors in mycobacteria. The enzyme is required for the replication and survival of the tubercle bacillus during the acute and chronic phases of infection in mice Mycobacterium tuberculosis