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Literature summary extracted from

  • Phong, W.; Lin, W.; Rao, S.; Dick, T.; Alonso, S.; Pethe, K.
    Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxia (2013), PLoS ONE, 8, e56037.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.11 expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Mycobacterium tuberculosis
-
-
-
2.7.1.11 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.11 Ni-NTA column chromatography and Superdex 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
Mycobacterium tuberculosis ADP + D-fructose 1,6-bisphosphate
-
?
2.7.1.11 ATP + D-fructose 6-phosphate
-
Mycobacterium tuberculosis H37Rv ADP + D-fructose 1,6-bisphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 PFKA isozyme Mycobacterium tuberculosis
2.7.1.11 phosphofructokinase
-
Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.1.11 physiological function isozyme PFKA is required for growth on glucose as sole carbon source. The isoform is also required for survival of hypoxic non-replicating Mycobaterium tuberculosis but is not required for virulence and survival in the mouse model of tuberculosis infection Mycobacterium tuberculosis