EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.7.1 | expressed in Escherichia coli BL21(DE3) cells | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.7.1 | 0.0252 | - |
nicotinamide ribonucleotide | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.0335 | - |
ATP | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.0385 | - |
nicotinamide ribonucleotide | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.039 | - |
ATP | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.082 | - |
ATP | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.1176 | - |
nicotinamide ribonucleotide | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.1 | Co2+ | isoform NMNAT3 is predominantly activated by Co2+ ions (5 mM) | Mus musculus | |
2.7.7.1 | Mg2+ | isoform NMNAT2 is predominantly activated by Mg2+ ions (0.5 mM) | Mus musculus | |
2.7.7.1 | Zn2+ | isoform NMNAT1 is predominantly activated by Zn2+ ions (0.05 mM) | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.1 | Mus musculus | Q5HZI3 | isoform NMNAT2 | - |
2.7.7.1 | Mus musculus | Q99JR6 | isoform NMNAT3 | - |
2.7.7.1 | Mus musculus | Q9EPA7 | isoform NMNAT1 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.7.1 | Ni-NTA affinity chromatography | Mus musculus |
2.7.7.1 | Talon affinity column chromatography | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.7.1 | brain | - |
Mus musculus | - |
2.7.7.1 | liver | - |
Mus musculus | - |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.7.1 | -20°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 20% loss of activity | Mus musculus |
2.7.7.1 | -20°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 55% loss of activity | Mus musculus |
2.7.7.1 | -20°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 60% loss of activity | Mus musculus |
2.7.7.1 | 4°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 55% loss of activity | Mus musculus |
2.7.7.1 | 4°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 60% loss of activity | Mus musculus |
2.7.7.1 | 4°C, at pH 7.5 in buffer containing both glycerol and TCEP, 6 months, about 90% loss of activity | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.1 | ATP + nicotinamide ribonucleotide | - |
Mus musculus | diphosphate + NAD+ | - |
r | |
2.7.7.1 | ATP + nicotinic acid mononucleotide | - |
Mus musculus | diphosphate + deamido-NAD+ | - |
r | |
2.7.7.1 | GTP + nicotinamide ribonucleotide | - |
Mus musculus | ? | - |
? | |
2.7.7.1 | ITP + nicotinamide ribonucleotide | - |
Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.1 | nicotinamide mononucleotide adenylyltransferase | - |
Mus musculus |
2.7.7.1 | NMNAT1 | isoform | Mus musculus |
2.7.7.1 | NMNAT2 | isoform | Mus musculus |
2.7.7.1 | NMNAT3 | isoform | Mus musculus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.7.1 | 0.74 | - |
ATP | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 0.75 | - |
nicotinamide ribonucleotide | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 2.33 | - |
ATP | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 2.87 | - |
nicotinamide ribonucleotide | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 15 | - |
ATP | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 15.5 | - |
nicotinamide ribonucleotide | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.7.1 | 10 | - |
nicotinamide ribonucleotide | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 20 | - |
ATP | isoform NMNAT3, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 30 | - |
ATP | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 70 | - |
nicotinamide ribonucleotide | isoform NMNAT2, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 450 | - |
ATP | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus | |
2.7.7.1 | 610 | - |
nicotinamide ribonucleotide | isoform NMNAT1, in 30 mM HEPES/KOH, pH 7.5, at 37°C | Mus musculus |