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Literature summary extracted from

  • Khare, G.; Kar, R.; Tyagi, A.K.
    Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs (2011), PLoS ONE, 6, e22441.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.3 expressed in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.3 3-benzylsulfanyl-phenanthro[9,10-e][1,2,4]triazine IC50 of 0.1 mg/ml Mycobacterium tuberculosis
2.5.1.3 4-[[(2-hydroxy-5-nitrophenyl)methylidene]amino]-5-methyl-2-(propan-2-yl)phenol IC50 of 0.034 mg/ml Mycobacterium tuberculosis
2.5.1.3 7-[[4-chloro-6-(diethylamino)-s-triazin-2-yl]amino]-3-phenyl-coumarin IC50 of more than 0.1 mg/ml Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.3 29000
-
 x * 29000, SDS-PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.3 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.3 strep - tactin column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.3 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
-
 Mycobacterium tuberculosis thiamine phosphate + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.3 ? x * 29000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.5.1.3 thiamin phosphate synthase
-
 Mycobacterium tuberculosis
2.5.1.3 TPS
-
 Mycobacterium tuberculosis