EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.20 | 3-(4-ethylphenyl)-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole | - |
Trypanosoma brucei | |
2.7.1.20 | 3-(4-phenoxyphenyl)-5-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole | - |
Trypanosoma brucei | |
2.7.1.20 | 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]morpholine | - |
Trypanosoma brucei | |
2.7.1.20 | 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine | best activator | Trypanosoma brucei | |
2.7.1.20 | 4-[[3-(4-phenoxyphenyl)-1H-pyrazol-5-yl]methyl]morpholine | - |
Trypanosoma brucei |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.20 | - |
Trypanosoma brucei |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.1.20 | in complex with the bisubstrate inhibitor P1,P5-di(adenosine-5')-pentaphosphate (at 16°C, in 0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate, pH 6.0, and 24% (w/v) polyethylene glycol 8000 (crystal form 1), or in 0.1 M tri-sodium citrate dihydrate, pH 5.6, 20% (v/v) isopropanol, and 20% (w/v) polytethylene glycol 4000 (crystal form 2)) and with the activator 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine (at 4°C in 0.1 M Tris, pH 9.0 and 60% (v/v) 2-methyl-2,4-pentanediol), sitting drop vapor diffusion method | Trypanosoma brucei |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.20 | P1,P5-di(adenosine-5')pentaphosphate | - |
Trypanosoma brucei |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.20 | Mg2+ | required | Trypanosoma brucei |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.20 | Trypanosoma brucei | Q584S0 | subsp. rhodesiense | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.20 | - |
Trypanosoma brucei |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.20 | ATP + adenosine | ATP is the preferred phosphoryl donor | Trypanosoma brucei | ADP + AMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.20 | ATP:adenosine 5'-phosphotransferase | - |
Trypanosoma brucei |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.20 | 43 | - |
the melting temperature of the apo-enzyme is at 43°C | Trypanosoma brucei |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.20 | 0.0294 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | P1,P5-di(adenosine-5')-pentaphosphate |