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Literature summary extracted from

  • Cronje, C.; George, G.M.; Fernie, A.R.; Bekker, J.; Kossmann, J.; Bauer, R.
    Manipulation of L-ascorbic acid biosynthesis pathways in Solanum lycopersicum: elevated GDP-mannose pyrophosphorylase activity enhances L-ascorbate levels in red fruit (2012), Planta, 235, 553-564.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.13 gene MPG1, recombinant overexpression in Solanum lycopersicum ripe, fruits show enhanced L-ascorbate levels Saccharomyces cerevisiae
2.7.7.13 recombinant functional overexpression of Saccharomyces cerevisiae gene MPG1 in Solanum lycopersicum, fruits show 17-31fold enhanced enzyme activity and L-ascorbate levels Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.13 GTP + alpha-D-mannose 1-phosphate Solanum lycopersicum
-
 diphosphate + GDP-mannose
-
 ?
2.7.7.13 GTP + alpha-D-mannose 1-phosphate Saccharomyces cerevisiae
-
 diphosphate + GDP-mannose
-
 ?
2.7.7.13 GTP + alpha-D-mannose 1-phosphate Saccharomyces cerevisiae FY23
-
 diphosphate + GDP-mannose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.13 Saccharomyces cerevisiae P41940 a S288C strain
-
2.7.7.13 Saccharomyces cerevisiae FY23 P41940 a S288C strain
-
2.7.7.13 Solanum lycopersicum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.13 fruit low enzyme activity levels in green and red fruits Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.13 GTP + alpha-D-mannose 1-phosphate
-
 Solanum lycopersicum diphosphate + GDP-mannose
-
 ?
2.7.7.13 GTP + alpha-D-mannose 1-phosphate
-
 Saccharomyces cerevisiae diphosphate + GDP-mannose
-
 ?
2.7.7.13 GTP + alpha-D-mannose 1-phosphate
-
 Saccharomyces cerevisiae FY23 diphosphate + GDP-mannose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.13 GDP-mannose pyrophosphorylase
-
 Solanum lycopersicum
2.7.7.13 GDP-mannose pyrophosphorylase
-
 Saccharomyces cerevisiae
2.7.7.13 GMPase
-
 Solanum lycopersicum
2.7.7.13 GMPase
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.13 7.5
-
 assay at Solanum lycopersicum
2.7.7.13 7.5
-
 assay at Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.7.7.13 additional information overexpression of GDP-mannose pyrophosphorylase from Saccharomyces cerevisiae in red fruits of Solanum lycopersicum enhances L-ascorbate levels Solanum lycopersicum
2.7.7.13 additional information overexpression of GDP-mannose pyrophosphorylase in red fruits of Solanum lycopersicum enhances L-ascorbate levels Saccharomyces cerevisiae