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Literature summary extracted from
- Homology modeling of the three membrane proteins of the dhurrin metabolon: catalytic sites, membrane surface association and protein-protein interactions (2011), Phytochemistry, 72, 2113-2123.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.37 | membrane | - |
Sorghum bicolor | 16020 | - |
| 2.4.1.85 | soluble | - |
Sorghum bicolor | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.37 | (E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2 | Sorghum bicolor | - |
(S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? |  |
| 2.4.1.85 | UDP-glucose + 4-hydroxymandelonitrile | Sorghum bicolor | - |
UDP + (S)-4-hydroxymandelonitrile beta-D-glucoside | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.37 | Sorghum bicolor | - |
- |
- |
| 2.4.1.85 | Sorghum bicolor | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.37 | (E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sorghum bicolor | (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? | |
| 2.4.1.85 | UDP-glucose + 4-hydroxymandelonitrile | - |
Sorghum bicolor | UDP + (S)-4-hydroxymandelonitrile beta-D-glucoside | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.37 | CYP71E1 | - |
Sorghum bicolor |
| 2.4.1.85 | UDP-glucosyltransferase | - |
Sorghum bicolor |
| 2.4.1.85 | UGT85B1 | - |
Sorghum bicolor |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.37 | NADPH | - |
Sorghum bicolor | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.4.1.85 | metabolism | UGT85B1 is an important step in product channelling because a rapid glucosylation of the labile p-hydroxymandelonitrile product of CYP71E1 is necessary to avoid its dissociation into p-hydroxybenzaldehyde and hydrogen cyanide | Sorghum bicolor |
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Release 2023.1 (January 2023)
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