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Literature summary extracted from

  • Rauchova, H.; Vokurkova, M.; Drahota, Z.
    Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin (2012), Physiol. Res., 61, 259-265.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.5.3 cytochrome c role of cyt c in activation of glycerol-3-phosphate and succinate oxidation in frozenthawed mitochondria Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.5.3 Digitonin strong inhibition, the activity is recovered to 148% of control values by the addition of exogenous synthetic analog of CoQ idebenone, i.e. hydroxydecylubiquinone, and cytochrome c. The compound also strongly activates glycerol-3-phosphate oxidation inhibited by endogenous or added free fatty acids Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.5.3 mitochondrial inner membrane
-
 Rattus norvegicus 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.5.3 sn-glycerol 3-phosphate + oxidized coenzyme Q Rattus norvegicus
-
 glycerone phosphate + reduced coenzyme Q
-
 ?
1.1.5.3 sn-glycerol 3-phosphate + oxidized coenzyme Q Rattus norvegicus Wistar
-
 glycerone phosphate + reduced coenzyme Q
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.5.3 Rattus norvegicus
-
-
-
1.1.5.3 Rattus norvegicus Wistar
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.5.3 liver very low activity Rattus norvegicus
-
1.1.5.3 thyroid gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.5.3 sn-glycerol 3-phosphate + oxidized coenzyme Q
-
 Rattus norvegicus glycerone phosphate + reduced coenzyme Q
-
 ?
1.1.5.3 sn-glycerol 3-phosphate + oxidized coenzyme Q
-
 Rattus norvegicus Wistar glycerone phosphate + reduced coenzyme Q
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.5.3 flavoprotein-dependent glycerol-3-phosphate dehydrogenase
-
 Rattus norvegicus
1.1.5.3 glycerol-3-phosphate oxidoreductase
-
 Rattus norvegicus
1.1.5.3 GPDH
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.5.3 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.5.3 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.5.3 coenzyme Q
-
 Rattus norvegicus