EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | Mg2+ | required | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2',2'-difluorodeoxycytidine | Homo sapiens | i.e. gemcitabine, transport and metabolism in vivo, overview | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
2.7.1.74 | ATP + deoxycytidine | Homo sapiens | - |
ADP + dCMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.74 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.74 | pancreatic cancer cell | - |
Homo sapiens | - |
2.7.1.74 | PK-9 cell | - |
Homo sapiens | - |
2.7.1.74 | RPK-9 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
2.7.1.74 | ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine, transport and metabolism in vivo, overview | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine monophosphate | - |
? | |
2.7.1.74 | ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.74 | dCK | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.74 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.74 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | ATP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.74 | malfunction | deoxxycytidine kinase inhibition causes gemcitabine resistance, overview | Homo sapiens |
2.7.1.74 | metabolism | 2',2'-difluorodeoxycytidine, i.e. gemcitabine, is phosphorylated intracellularly via multiple steps, and the triphosphate inhibits DNA synthesis by interfering with incorporation of endogenous dCTP into DNA, deocycytidine kinase catalyzes the first phosphorylation step, overview | Homo sapiens |