Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ohmine, K.; Kawaguchi, K.; Ohtsuki, S.; Motoi, F.; Egawa, S.; Unno, M.; Terasaki, T.
    Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells (2012), Pharm. Res., 29, 2006-2016.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, transport and metabolism in vivo, overview ADP + 2',2'-difluorodeoxycytidine monophosphate
-
?
2.7.1.74 ATP + deoxycytidine Homo sapiens
-
ADP + dCMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 pancreatic cancer cell
-
Homo sapiens
-
2.7.1.74 PK-9 cell
-
Homo sapiens
-
2.7.1.74 RPK-9 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2',2'-difluorodeoxycytidine i.e. gemcitabine Homo sapiens ADP + 2',2'-difluorodeoxycytidine monophosphate
-
?
2.7.1.74 ATP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, transport and metabolism in vivo, overview Homo sapiens ADP + 2',2'-difluorodeoxycytidine monophosphate
-
?
2.7.1.74 ATP + deoxycytidine
-
Homo sapiens ADP + dCMP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.74 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.74 7.4
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.74 malfunction deoxxycytidine kinase inhibition causes gemcitabine resistance, overview Homo sapiens
2.7.1.74 metabolism 2',2'-difluorodeoxycytidine, i.e. gemcitabine, is phosphorylated intracellularly via multiple steps, and the triphosphate inhibits DNA synthesis by interfering with incorporation of endogenous dCTP into DNA, deocycytidine kinase catalyzes the first phosphorylation step, overview Homo sapiens