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Literature summary extracted from

  • Suspene, R.; Sommer, P.; Henry, M.; Ferris, S.; Guetard, D.; Pochet, S.; Chester, A.; Navaratnam, N.; Wain-Hobson, S.; Vartanian, J.P.
    APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase (2004), Nucleic Acids Res., 32, 2421-2429.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.B9 cytosine in single-stranded viral DNA + H2O Homo sapiens cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') uracil in single-stranded viral DNA + NH3
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.B9 Homo sapiens Q9HC16
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.B9 cytosine in single-stranded viral DNA + H2O cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') Homo sapiens uracil in single-stranded viral DNA + NH3
-
 ?
3.5.4.B9 additional information the enzyme alone extensively deaminates cDNA independently of reverse transcriptase. The cDNA has to be free of its RNA template to allow deamination. Deoxycytosine or dCTP are poor substrates Homo sapiens ?
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 ?
3.5.4.B9 TTTCCCCGC + H2O sequence with highest deamination rate Homo sapiens TTTCCUCGC + NH3
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.B9 APOBEC3G
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 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.4.B9 physiological function APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication Homo sapiens