Literature summary extracted from

Bini, F.; Frati, A.; Garcia-Gil, M.; Battistini, C.; Granado, M.; Martinesi, M.; Mainardi, M.; Vannini, E.; Luzzati, F.; Caleo, M.; Peretto, P.; Gomez-Munoz, A.; Meacci, E.
New signalling pathway involved in the anti-proliferative action of vitamin D3 and its analogues in human neuroblastoma cells. A role for ceramide kinase (2012), Neuropharmacology, 63, 524-537.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.138	1alpha,25-dihydroxyvitamin D3	enzyme activity decreases by approximately 40% in the presence of the hormone	Homo sapiens
2.7.1.138	ZK191784	enzyme activity decreases by approximately 25% in the presence of the hormone analogue	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.138	Homo sapiens	Q8TCT0	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.138	SH-SY5Y cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.1.138	CERK	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.7.1.138	Homo sapiens	expression of the enzyme, after 24 h of treatment with 1alpha,25-dihydroxyvitamin D3 or its analogue ZK191784, is reduced by approximately 40 and 60%, respectively	down

General Information

EC Number	General Information	Comment	Organism
2.7.1.138	physiological function	ceramide kinase/ceramide 1-phosphate axis acts as molecular effector of the anti-proliferative action of 1alpha,25-dihydroxyvitamin D3 and its analogues. The inhibition of ceramide kinase by specific gene silencing or pharmacological inhibition, drastically reduces cell proliferation. 1alpha,25-Dihydroxyvitamin D3 and structural analogue ZK191784 treatment induce a significant decrease in ceramide kinase expression and ceramide 1-phosphate content, and an increase of ceramide. The treatment of SH-SY5Y cells with ZK159222, antagonist of 1alpha,25-dihydroxyvitamin D3 receptor, trichostatin A, inhibitor of histone deacetylases, and COUP-TFI-siRNA prevents the decrease of ceramide kinase expression elicited by 1alpha,25-dihydroxyvitamin D3 supporting the involvement of VDR/COUP-TFI/histone deacetylase complex in ceramide kinase regulation	Homo sapiens

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Release 2023.1 (January 2023)