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Literature summary extracted from

  • Huang, Z.; Anderson, R.E.; Cao, W.; Wiechmann, A.F.; Rajala, R.V.
    Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase (2011), Neurochem. Res., 36, 627-635.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.149 quantitative real-time PCR expression analysis, expression of isozyme PIPKIIalpha in Xenopus laevis oocytes Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.149 photoreceptor inner segment
-
 Rattus norvegicus 1917
-
2.7.1.149 photoreceptor outer segment
-
 Mus musculus 1750
-
2.7.1.149 photoreceptor outer segment
-
 Rattus norvegicus 1750
-
2.7.1.149 photoreceptor outer segment membrane
-
 Mus musculus 42622
-
2.7.1.149 photoreceptor outer segment membrane
-
 Rattus norvegicus 42622
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.149 Mg2+ required Mus musculus
2.7.1.149 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Rattus norvegicus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Rattus norvegicus Sprague-Dawley
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Mus musculus
-
-
-
2.7.1.149 Rattus norvegicus
-
-
-
2.7.1.149 Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.149 eye
-
 Mus musculus
-
2.7.1.149 eye
-
 Rattus norvegicus
-
2.7.1.149 additional information light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the ROS membrane Mus musculus
-
2.7.1.149 additional information light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the ROS membrane Rattus norvegicus
-
2.7.1.149 photoreceptor cell quantitative real-time PCR enzyme expression analysis Mus musculus
-
2.7.1.149 retina
-
 Rattus norvegicus
-
2.7.1.149 retina quantitative real-time PCR enzyme expression analysis Mus musculus
-
2.7.1.149 retinal rod inner segment Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Rattus norvegicus Sprague-Dawley ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 PIPKIIalpha
-
 Mus musculus
2.7.1.149 PIPKIIalpha
-
 Rattus norvegicus
2.7.1.149 type II alpha phosphatidylinositol-5-phosphate 4-kinase
-
 Mus musculus
2.7.1.149 type II alpha phosphatidylinositol-5-phosphate 4-kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.149 ATP
-
 Mus musculus
2.7.1.149 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.1.149 evolution two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell Mus musculus
2.7.1.149 evolution two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell Rattus norvegicus
2.7.1.149 physiological function greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase Mus musculus
2.7.1.149 physiological function greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase Rattus norvegicus