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Literature summary extracted from

  • Zhang, H.; Yang, B.; Pomerantz, R.J.; Zhang, C.; Arunachalam, S.C.; Gao, L.
    The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA (2003), Nature, 424, 94-98.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.B9 glutathione S-transferase-tagged enzyme is expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.B9 C288A/C291A the mutant enzyme shows about 18% activity compared to the wild type enzyme Homo sapiens
3.5.4.B9 C97A/C100A the mutant enzyme shows about 18% activity compared to the wild type enzyme Homo sapiens
3.5.4.B9 H257A the mutant enzyme shows about 10% activity compared to the wild type enzyme Homo sapiens
3.5.4.B9 H81A the mutant enzyme shows about 25% activity compared to the wild type enzyme Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.B9 Zn2+ contains two zinc finger domains Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.B9 cytosine in single-stranded viral DNA + H2O Homo sapiens
-
 uracil in single-stranded viral DNA + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.B9 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.B9
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.B9 HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.B9 cytosine in single-stranded viral DNA + H2O
-
 Homo sapiens uracil in single-stranded viral DNA + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.B9 APOBEC3G
-
 Homo sapiens
3.5.4.B9 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
-
 Homo sapiens
3.5.4.B9 CEM15
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.4.B9 physiological function the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA Homo sapiens